There has always been antagonism against the people of God. From the earliest days Esau would seek the death of Jacob, Cain slew Abel and Goliath sought occasion against the God of the Jews

The capital of Rome, and the head of the catholic roman church, vatican stands in a unique places in history. It has been repsonsible for the inquisition against any who would stand against their bulls, and claims divine sanctions from the apostle Peter

One system will stand against Christ at his coming it is described in the words: “a woman, a great city that reigneth over the kings of the earth” Rev 17:18,35.239128&sspn=0.001366,0.003264&ie=UTF8&hq=&hnear=Vatican+City&ll=41.902277,12.456522&spn=0.019133,0.052228&t=h&z=15